Jumpy the dog skateboards and jumps off walls in this amazing stunt video

Just as the name of his new video states, Jumpy is one ?badass dog,? performing 20 incredible stunts in this 1-minute clip.

The Australian border collie walks through a series of traffic cones on his front paws, leaps through the air into his trainer?s arms and even a number of stunts on a skateboard that most humans would find beyond their ability.

His owner, Omar Von Muller, has a long-history of training exceptional dogs. He's best known for training ?Uggie? from the Academy Award winning film, ?The Artist.? In a 2012 interview, Von Muller said there is no magic to his incredible dog training results, that it simply comes down to finding the right dog and putting in the hours.? Still, that's easier said than done for most dog owners.

?My advice would be train and make sure you practice consistency,? he said. ?I?ve been training for about 30 plus years myself.?

Though, let's give credit where credit is due. Mainly, to Jumpy himself. Or, as one YouTube commenter notes, ?You're an amazing and? inspirational trainer, but I'm afraid that you don't hold a candle to the stardom of your dogs.?

Source: http://news.yahoo.com/blogs/sideshow/jumpy-dog-skateboards-jumps-off-walls-amazing-stunt-210012429.html

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Two charged in bribe probe related to New York mayor's race (reuters)

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How antibodies neutralize mosquito-borne virus

Apr. 2, 2013 ? Researchers have learned the precise structure of the mosquito-transmitted chikungunya virus pathogen while it is bound to antibodies, showing how the infection is likely neutralized.

The findings could help researchers develop effective vaccines against the infection, which causes symptoms similar to dengue fever, followed by a prolonged disease that affects the joints and causes severe arthritis. In recent outbreaks, some cases progressed to fatal encephalitis.

The researchers studied "virus-like particles," or non-infectious forms of the virus. They also obtained near atomic-scale resolution of the virus attached to four separate antibodies.

"We knew these antibodies neutralize the real virus, so we wanted to know how they do it," said Michael Rossmann, Purdue University's Hanley Distinguished Professor of Biological Sciences.

Findings are detailed in a research paper appearing Tuesday (April 2) in the journal eLife.

The scientists used a technique called cryoelectron microscopy to uncover critical structural details about the virus-like particles bound to the antibodies. The particles are made of 180 "heterodimers," molecules made of two proteins: envelope protein 1, or E1, and envelope protein 2, or E2.

The findings show the precise structure of the virus-like particle bound to a key part of the antibodies, called the antigen binding fragment, or Fab, which attaches to the heterodimers making up the virus's outer shell. The analyses showed that the antibodies stabilize the viral surface, hindering fusion to the host cell and likely neutralizing infection.

Chikungunya is an alphavirus, a family of viruses that includes eastern equine encephalitis.

"This is the first time the structure of an alphavirus has been examined in this detail," Rossmann said.

The research is aimed at learning precisely how viruses infect humans and other hosts, knowledge that may lead to better vaccines and antiviral drugs, Rossmann said.

Chikungunya in 2005 caused an epidemic on R?union Island. A mutation in the E1 protein has allowed the virus to replicate more efficiently, which is considered the primary reason for its recent extensive spread, infecting millions of people in Africa and Asia.?

The research team conducted experiments to record the structure of the virus in different orientations and obtained a three-dimensional structure with a resolution of 5.3 ?ngstroms, or 5.3 ten-billionths of a meter.

The research, funded by the NIH, is ongoing and involves one graduate student and five postdoctoral students. One goal is to learn how the virus is modified when the antibodies bind to the virus and to obtain higher-resolution images.

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Story Source:

The above story is reprinted from materials provided by Purdue University. The original article was written by Emil Venere.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. S. Sun, Y. Xiang, W. Akahata, H. Holdaway, P. Pal, X. Zhang, M. S. Diamond, G. J. Nabel, M. G. Rossmann. Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization. eLife, 2013; 2 (0): e00435 DOI: 10.7554/eLife.00435

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/Cfy9Tl7N-yY/130402125044.htm

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Texas community in 'shock' over slaying of DA, wife

Texas district attorney Mike McClelland and his wife Cynthia were found dead, just two months after McClelland's top assistant was also shot dead. Authorities are exploring a link between the two crimes and a possible link to a ?white supremacist group. NBC's Gabe Gutierrez reports.

By Erin McClam and John Newland, NBC News

An official in the Texas county where a prosecutor and his wife were shot to death over the weekend said Monday that the ordeal was ?surreal? and that authorities there were on alert.

?We?re still in shock,? Kaufman County Judge Bruce Wood told reporters.

District Attorney Mike McLelland and his wife, Cynthia, were gunned down at their home outside Dallas on Saturday two months after another prosecutor there was shot to death.

A white supremacist group has been thought to be planning retaliation after indictments in a racketeering case, and the state has recently warned about Mexican drug cartels.

But authorities have not said the killings of the two prosecutors are linked and have not announced any leads in the McLellands? deaths.

?We are very much on alert,? Wood said. ?We have some folks out there that intend to do harm to public officials.?

He said that the county was open for business.

McLelland had vowed to catch the killer of the other prosecutor, Assistant District Attorney Mark Hasse, who was gunned down near the county courthouse on his way to work Jan. 31.

McLelland told reporters that day: ?I hope the people that did this are watching. Because we're very confident that we're going to find you, pull you out of whatever hole you're in, bring you back and let the people of Kaufman County prosecute you to the fullest extent of the law.?

Gov. Rick Perry on Monday urged law enforcement officers to be careful.

Investigative Crime Reporter Michelle Sigona and Tanya Eiserer from the "Dallas Morning News" join Tamron Hall to discuss the murder of Texas prosecutor, Mike Mclelland and wife Cynthia.

?This I think is a clear concern to individuals who are in public life, particularly those who deal with some very mean and vicious individuals, whether they?re white supremacy groups or whether they're the drug cartels that we have,? he said.

Mayor Darren Rozell of Forney, which is in Kaufman County, told NBC News after McLelland?s killing that it appeared to be targeted and that civilians probably were not at risk.

Asked about suggestions that a white supremacist group may have been involved, Rozell said he had seen media reports to that effect but ?really couldn?t comment.?

On the day Hasse was killed, the Justice Department announced that the Kaufman County DA?s office was among investigative bodies involved in a racketeering case against the white supremacist group Aryan Brotherhood of Texas.

A district attorney and his wife were found shot dead in their Texas home on Saturday, a chilling crime that has become a murder mystery. NBC's Gabe Gutierrez reports.

The hate group was suspected of ?actively planning retaliation? against police and prosecutors who helped gain indictments in Houston against dozens of its members, the Dallas Morning News reported in February.

Rep. Ted Poe, a Republican and former Texas prosecutor, told CNN that his suspicions in the McLelland killing centered on the Aryan Brotherhood, a white supremacy group, but he did not say where he was getting his information.

In February, the state's Department of Public Safety issued a report highlighting the threat of Mexican drug cartels operating in Texas.

The FBI and the Texas Rangers were leading the investigations, which at one point examined possible ties to the March 19 shooting death of Colorado prisons director Tom Clements, Reuters reported, adding that no connection had been found.

The McLellands were ?deeply in love,? Tonya Ratcliff, the county tax assessor and a longtime friend of the couple, told NBCDFW.com.

?You would never hear one of them say an ugly word about the other one,? she said. "They were just a wonderful couple, and it was a pleasure to be around them ? and I will miss them.?

A tip line has been set up for the investigation. Anyone with information to share with investigators is asked to call 1-877-847-7522.

Reuters contributed to this report.

Related:

District attorney, wife shot to death in Texas county where assistant DA was killed, police say

This story was originally published on Mon Apr 1, 2013 5:52 AM EDT

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/2a386905/l/0Lusnews0Bnbcnews0N0C0Inews0C20A130C0A40C0A10C175490A0A0A0Etexas0Ecommunity0Ein0Eshock0Eover0Eslaying0Eof0Eda0Ewife0Dlite/story01.htm

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Queueing Theory Lets Any App Offer A Mailbox-Like Reservation System (Even If It's Just For Building Buzz)

Ever since Google announced that access to its then new email application Gmail would be invite-only at first, startup founders have been angling to reproduce that same kind of fervor for their own services. But it wasn’t until the new iOS app Mailbox launched its innovative “reservation system” that we’ve seen anything come close to replicating the same level of demand that Gmail saw back in the day. And now, a new San Francisco-based company known as?Queueing Theory wants to bring a Mailbox-like reservation system to any startup – especially those targeting mobile users. Mailbox, which was recently acquired by Dropbox, generated interest in its application?by first collecting sign-ups at a dedicated URL. Users were given a reservation number via SMS, which marked their place in line, as well as a Private Code to unlock the app once it became available in the App Store. Though the company claimed that using reservations helped it with the strain on its servers, the system had another side effect as well – it made the buzzy new app feel like an exclusive club which only the coolest early adopters could access. Now other applications, like newly launched “smart calendar” Tempo, are utilizing similar systems – in Tempo’s case, it’s claiming that their efforts require “significant up-front email processing,” necessitating a reservation system of its own. But why limit this feature only to email or calendaring apps? As any startup founder can tell you, getting hit by a heavy load of users can tank your servers quickly, leading to a poor user experience. That’s where Queueing Theory comes in. It will introduce a Mailbox-like reservation system designed with the needs of mobile app developers in mind. Though the system has a web interface, it’s being targeted specifically at those who want to launch in the Apple App Store (and soon, on Android, too) before actually having the server capacity to support sign-ups from the general public. Instead, users can sign up for their spot directly from the app, or from the startup’s homepage. After providing their email address, users are given a spot in line, which is sent via SMS and appears upon subsequent app launches. Where the company’s system varies from what Mailbox introduced, however, is that it’s building out a whole social network just for signing up for new App Store apps which are live, but only for “special” users. Startups can

Source: http://feedproxy.google.com/~r/Techcrunch/~3/PkTNFNAxxhw/

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All water pills not equally effective against heart failure

Apr. 1, 2013 ? Loop diuretics, more commonly known as water pills, are the most widely prescribed heart failure medications, but few studies had extensively compared their effectiveness until Yale School of Medicine researchers examined three approved loop diuretics and found that even though one of them might offer more benefit, it is rarely prescribed.

Published in the April 1 early edition of the Journal of the American College of Cardiology, the research compared the potential benefits of using one of three loop diuretics: toresemide, furosemide, and bumetanide.

"Loop diuretics are a cornerstone of heart failure treatment, so it is vital to understand the comparative effectiveness and real-world use of the drugs within this class," said lead author Dr. Behnood Bikdeli, postdoctoral associate in cardiovascular medicine at the Yale Center for Outcomes Research and Evaluation (CORE).

With over 5 million Americans suffering from heart failure, Bikdeli said that improving existing treatment options is key to providing the best care.

The team found that among 274,515 hospitalizations for heart failure during 2009 and 2010 across a large group of U.S. hospitals, 92% received loop diuretics during their hospital stay. Of those, 87% received furosemide as their only loop diuretic, 3% received bumetanide, and only 0.4% received torsemide, while 10% received a combination of these agents.

Although torsemide is slightly more expensive, the few available studies suggest that it lasts longer, is better tolerated, and might be associated with better clinical outcomes compared with the two other available water pills.

"There appears to be potential benefits from using torsemide compared with furosemide, but it is rarely used in practice," said Bikdeli. "Furosemide is the dominantly used loop diuretic in practice; however, if the potential advantages of torsemide over furosemide are proven in subsequent comparative effectiveness studies, this drug might become the preferred treatment of chronic heart failure."

Other authors on the study include Kelly Strait, Kumar Dharmarajan, Chohreh Partovian, Steven Coca, Nancy Kim, Shu-Xia Li, Jeffrey Testani, Usman Khan, and Harlan Krumholz.

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The above story is reprinted from materials provided by Yale University. The original article was written by Karen N. Peart.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Behnood Bikdeli, Kelly M. Strait, Kumar Dharmarajan, Chohreh Partovian, Steven G. Coca, Nancy Kim, Shu-Xia Li, Jeffrey M. Testani, Usman Khan, Harlan M. Krumholz. Dominance of Furosemide for Loop Diuretic Therapy in Heart Failure. Journal of the American College of Cardiology, 2013; 61 (14): 1549 DOI: 10.1016/j.jacc.2012.12.043

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/heart_disease/~3/XEFp3w63zFg/130401161426.htm

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Fairview Gun Club promotes sportsmanship, recreation - Sports ...

COAL TOWNSHIP - Nestled on a hillside near the campus of the Shamokin Area School District on almost 600 acres of land, the Fairview Gun Club is dedicated to the love and preservation of outdoor recreation.

Since being formed more than 90 years ago, the club has operated with the specific goals of promoting good will, friendship and sportsmanship among its members while advancing wildlife conservation.

"We have a membership roster hanging on the wall, but it's more like a family record," recording secretary Dave Navrocki said.

The club was founded in 1922 and originated at the site where the Shamokin Area Middle-High School now stands. What started as nine members meeting in a tar paper shack has evolved into an organization that boasts nearly 1,000 members throughout the country.

When club land was needed to construct the new high school, Fairview moved, in 1972, to its present location on a hillside that overlooks the schools. Members now oversee 321 acres of woodlands which the organization owns and another 286 acres that it leases.

A variety of activities are available on the grounds for members to enjoy, including hunting, fishing, archery practice using 3-D targets and shooting ranges. The gun club has its own pond where it holds an annual trout derby, picnic grounds that are available to community organizations and a horseshoe pit where the club hosts a Father's Day tournament.

"As long as I have been a part of it, and many years before that, Fairview has always worked to keep the grounds the club stands on stocked for hunters and fishermen who are part of the club," financial secretary Ron Manney said.

In the past, the club has stocked its own pond for its annual youth trout derby, and put out between 150 and 240 ringneck pheasants every small game season for youth and adult pheasant hunting.

"Last year at our trout derby, a 12-year-old caught a fish that was between 22 and 23 inches long," Manney said. "That is something that young man will remember all his life. It may instill a love of fishing and being outdoors in him, and he may even be a future member of the club."

In recent months, most people outside of the membership only heard about the club from articles detailing legal problems related to gambling and alcohol violations. Manney and Navrocki said those problems have all been resolved and the club continues its self-described purpose, preserving wildlife and the land.

While Fairview is a private club, it regularly opens its grounds to the public for fund raising and community events. The club is the host for the annual Little Eddie Griffiths Memorial Scholarship Pig Roast, and hosts a trout derby and Easter egg hunt for the community.

"We work to raise money for several community organizations, such as the Salvation Army," Manney said. "We also have a scholarship fund for welders at the Northumberland County Career and Technology Center, and so much more," Manney said.

"It doesn't matter if it's something we need on gun club land, or something for the community," Navrocki said. "Our members will band together to get the job done."

Some individuals will always be on the grounds of the club as Fairview maintains a small cemetery for members and their families.

Navrocki said club members are looking forward to celebrating Fairview's 100th birthday in 2022 and that the little "diamond in the rough" 600 acres wide will remain as it is for many years to come.

"Some may have lost their way in the past with the past violations, but this club has been and always will be a sportsman's club to support outdoor activities, wildlife conservation and the community that it calls home," Navrocki said.

Club officers are president Robert Nahodil Jr., vice president Richard Drumheiser Jr., treasurer Robert Milbrand, recording secretary Dave Navrocki, financial secretary Ron Manney, trustees Dan Cotter, Rich Lahr Jr., Quentin Hummel, Dave Wolf, Jim Moreis and Rich Drumheiser Sr., land manager Jeremy Dixon, field captain Lloyd Parker and sergeant-at arms Don Koshinskie.

Source: http://newsitem.com/sports/fairview-gun-club-promotes-sportsmanship-recreation-1.1465842

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